Anti-CDH1 antibody

Anti-CDH1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Rat CDH1

WB, ELISA, ICC/IF, IF

Rat E-Cadherin / CDH1 / E-cad / CD324

E-cad antibody; AA960649 antibody; Arc-1 antibody; CD324 antibody; CDH1 antibody; Cdh1 antibody; CDHE antibody; Ecad antibody; ECAD antibody; E-Cadherin antibody; E-Cadherin antibody; LCAM antibody; L-CAM antibody; MGC107495 antibody; Um antibody; UVO antibody; UVO antibody; ARC-1 antibody; E-cad antibody; UVO antibody; CDHE antibody; ECAD antibody; LCAM antibody; Arc-1 antibody; CD324 antibody; Um antibody; UVO antibody; Ecad antibody; E-cad antibody; L-CAM antibody; AA960649 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Rat E-Cadherin / CDH1 / E-cad / CD324 . E-Cadherin / CDH1 / E-cad / CD324 specific IgG was purified by Rat E-Cadherin / CDH1 / E-cad / CD324 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas.