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Antimicrobial peptides

Antimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majority of known AMPs are cationic peptides with common structural characteristics where domains of hydrophobic and cationic amino acids are spatially arranged into an amphipathic design, which facilitates their interaction with bacterial membranes (Shai Y 2002; Yeaman MR & Yount NY 2003; Brown KL & Hancock RE 2006; Dennison SR et al. 2005; Zelezetsky I & Tossi A 2006). It is generally excepted that the electrostatic interaction facilitates the initial binding of the positively charged peptides to the negatively charged bacterial membrane. Moreover, the structural amphiphilicity of AMPs is thought to promote their integration into lipid bilayers of pathogenic cells, leading to membrane disintegration and finally to the microbial cell death. In addition to cationic AMPs a few anionic antimicrobial peptides have been found in humans, however their mechanism of action remains to be clarified (Lai Y et al. 2007; Harris F et al. 2009; Paulmann M et al. 2012). Besides the direct neutralizing effects on bacteria AMPs may modulate cells of the adaptive immunity (neutrophils, T-cells, macrophages) to control inflammation and/or to increase bacterial clearance.

AMPs have also been referred to as cationic host defense peptides, anionic antimicrobial peptides/proteins, cationic amphipathic peptides, cationic AMPs, host defense peptides and alpha-helical antimicrobial peptides (Brown KL & Hancock RE 2006; Harris F et al. 2009; Groenink J et al. 1999; Bradshaw J 2003; Riedl S et al. 2011; Huang Y et al. 2010).

The Reactome module describes the interaction events of various types of human AMPs, such as cathelicidin, histatins and neutrophil serine proteases, with conserved patterns of microbial membranes at the host-pathogen interface. The module includes also proteolytic processing events for dermcidin (DCD) and cathelicidin (CAMP) that become functional upon cleavage. In addition, the module highlights an AMP-associated ability of the host to control metal quota at inflammation sites to influence host-pathogen interactions.

Cat#Product NameSizePrice
300468Antimicrobial peptide, Pleurocidin-like peptide AP25 mg287.5
301163Antimicrobial peptide [I12]5 mg106.7
301165Antimicrobial peptide, Aurein 4.15 mg264.5
301194Antimicrobial peptide, Lactococcin G beta5 mg402.5
301209Antimicrobial peptide, Maculatin 1.25 mg276.0
301604Antimicrobial peptide, Maculatin 4.15 mg276.0
301751Antimicrobial peptide, Temporin-1Gd5 mg161.0
301766Antimicrobial peptide, Maximin S15 mg161.0
301780rCRAMP (rat cathelin-related antimicrobial peptide, cathelicidin; animals)5 mg391.0
302615Antimicrobial peptide, Cecropin C1/C25 mg320.0
302919Antimicrobial peptide cathelicidin FALL-395 mg346.7
302980Antimicrobial peptide, Cecropin B1/B25 mg414.0
303127Antimicrobial peptide, Uperin 3.75 mg195.5
303241Antimicrobial peptide, Caerin 1.85 mg222.3
303849Antimicrobial peptide, Pleurocidin-like peptide GcSc4C55 mg287.5
303866Antimicrobial peptide, Caerin 2.35 mg287.5
303909Putative antimicrobial peptide Z5 mg264.5
303920Antimicrobial peptide, Propherin-185 mg160.0
304118Antimicrobial peptide 15 mg138.0
304362Putative antimicrobial peptide X5 mg356.5
304448Antimicrobial peptide, Cecropin5 mg391.0
304477Antimicrobial peptide 15, Brevinin-1ARa5 mg304.5
304479Antimicrobial peptide, Cecropin A25 mg414.0
304546Antimicrobial peptide Amurin-25 mg138.0
304577Antimicrobial peptide cathelicidin FALL-395 mg448.5
304662Antimicrobial peptide, Uperin 2.65 mg218.5
304669Antimicrobial peptide, Metchnikowin A25 mg299.0
304725Antimicrobial peptide, Caerin 1.7.15 mg264.5
304782Antimicrobial peptide cathelicidin FALL-395 mg346.7
304913Antimicrobial peptide, Maximin 35 mg310.5
304922Antimicrobial peptide Japonicin-2CHd5 mg277.8
304931Antimicrobial peptide, Uperin 3.45 mg126.5
305028Antimicrobial peptide, Aurein 4.25 mg264.5
305252Antimicrobial peptide, Cecropin C5 mg425.5
305469Antimicrobial peptide 35 mg287.5
305571Antimicrobial peptide cathelicidin FALL-395 mg448.5
305894Antimicrobial peptide, Caerin 1.6.15 mg264.5
305930Antimicrobial peptide Japonicin-2CHc5 mg277.8
306111Antimicrobial peptide cathelicidin FALL-395 mg448.5
306131Antimicrobial peptide, Styelin D5 mg293.4
306263Antimicrobial peptide cathelicidin FALL-395 mg448.5
306284Antimicrobial peptide, Lactococcin G alpha15 mg448.5
306289Antimicrobial peptide, Caerin 1.1.15 mg264.5
306424Antimicrobial peptide clone 45 mg195.5
306531Antimicrobial peptide cathelicidin FALL-395 mg346.7
306884Antimicrobial peptide, Caerin 1.115 mg287.5
306923Cathelin-related antimicrobial peptide5 mg437.0
306924Antimicrobial peptide, Uperin 5.15 mg149.5
307455Antimicrobial and insecticidal peptide, Ponericin W55 mg276.0
307459Antimicrobial peptide cathelicidin FALL-395 mg448.5
307496Antimicrobial peptide, Frenatin 45 mg276.0
307547Antimicrobial peptide, PvHCt5 mg264.5
307552Antimicrobial peptide, Dermaseptin-like peptide PBN15 mg230.0
307566Antimicrobial peptide cathelicidin FALL-395 mg448.5
307951Putative antimicrobial peptide clone 65 mg151.1
308057Antimicrobial peptide, Clavanin C5 mg264.5
308292Antimicrobial peptide cathelicidin FALL-395 mg448.5
308332Antimicrobial peptide Japonicin-2CHa5 mg286.7
308760Antimicrobial peptide, Aurein 3.1.15 mg124.5
309026Antimicrobial peptide Amurin-15 mg456.5
309147Antimicrobial peptide, Clavanin D5 mg264.5
309292Antimicrobial peptide, Uperin 3.25 mg207.0
309341Antimicrobial peptide, Esculentin 1[19-46]5 mg422.0
309578Antimicrobial peptide, Kassinatuerin-1 [4-20]5 mg195.5
309664Antimicrobial peptide, Aurein 5.15 mg222.3
309849Antimicrobial peptide, Pleurocidin-like peptide NRC-015 mg276.0
310459Antimicrobial peptide, Phylloxin5 mg218.5
310648Antimicrobial peptide, Aurein 3.3.15 mg133.4
310690Antimicrobial peptide, [K18]-Moronecidin5 mg186.7
310774Antimicrobial peptide, Cecropin B5 mg320.0
310856Antimicrobial peptide, Pleurocidin-like peptide Hb185 mg276.0
310871Antimicrobial peptide, Aurein 4.45 mg264.5
310922Antimicrobial peptide, Caerin 1.135 mg276.0
310925Putative antimicrobial peptide clone 55 mg151.1
311000Antimicrobial peptide, Gaegurin 5 [K17]5 mg313.4
311108Antimicrobial peptide cathelicidin FALL-395 mg448.5
311159Antimicrobial peptide, Pleurocidin-like peptide GcSc4B75 mg230.0
311810Antimicrobial peptide, Uperin 3.35 mg207.0
311818Antimicrobial peptide cathelicidin FALL-395 mg448.5
311914Antimicrobial peptide, Pleurocidin-like peptide psi25 mg195.5
312259Antimicrobial peptide, Lactococcin G alpha25 mg356.5
312306Antimicrobial peptide, Pleurocidin-like peptide WF1a5 mg222.3
312742Antimicrobial peptide, Pleurocidin-like peptide psi35 mg264.5
312797Antimicrobial peptide cathelicidin FALL-395 mg448.5
312828Antimicrobial peptide, Aurein 4.35 mg264.5
312901Antimicrobial peptide [Lys23] CAP-75 mg425.5
313132Antimicrobial peptide, Styelin C5 mg284.5
313282Antimicrobial peptide, Aurein 2.45 mg184.0
313383Antimicrobial peptide, Caerin 1.4.15 mg115.0
313593Antimicrobial peptide, [R18]-Moronecidin5 mg241.5
313919Antimicrobial peptide, Aurein 3.1.25 mg161.0
313944Antimicrobial peptide, Esculentin 2P5 mg525.5
314346Antimicrobial peptide, Pleurocidin-like peptide WF35 mg222.3
314429Antimicrobial peptide [Asp23]CAP-75 mg425.5
314482Hematopoietic antimicrobial peptide-295 mg333.5
314540Antimicrobial peptide, Ceratotoxin D5 mg414.0
315118Antimicrobial peptide, Brevinin-1S5 mg376.0
315156Antimicrobial peptide, Uperin 6.25 mg345.0
315163Antimicrobial peptide, Uperin 6.15 mg266.7
315462Antimicrobial peptide, MAP-345 mg302.3
315564Antimicrobial peptide, Kassinatuerin-1 [4-18]5 mg172.5
315907Antimicrobial peptide cathelicidin FALL-395 mg448.5
316081Antimicrobial peptide, Aurein 2.1.15 mg161.0
317589Antimicrobial peptide VGF[554-577]5 mg276.0