Anti-E Cadherin (7H12) Mouse antibody

Anti-E Cadherin (7H12) Mouse antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

E Cadherin (7H12) Mouse monoclonal antibody

WB, IHC-P, FC

Human, Mouse, Monkey

Mouse IgG1

Antigen: Purified recombinant fragment of human CDH1 expressed in E. Coli.

Monoclonal

Ascitic fluid containing 0.03% sodium azide.

Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Swiss-Prot Acc.P12830.E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.