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Product Name
Anti-E Cadherin Rabbit antibody
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Description
E Cadherin Rabbit polyclonal antibody
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Tested applications
WB, IP
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Species reactivity
Mouse, Rat
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Alternative names
Um; UVO; Ecad; ARC-1; E-cad; L-CAM; AA960649 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of mouse E Cadherin
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
IP: 1/20
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Validations
Western blot detection of E Cadherin in Mouse brain lysates using E Cadherin Rabbit pAb(1:1000 diluted).Predicted band size:98(cleavages),135KDa.Observed band size: 80-120(cleavages),135KDa.
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Background
Swiss-Prot Acc.P09803.Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 .
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"