E-cadherin antibody

E-cadherin antibody

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E-cadherin Mouse Monoclonal antibody. Positive WB detected in A431 cells, MCF-7 cells. Positive IHC detected in human breast cancer tissue. Positive IF detected in human breast cancer tissue. Observed molecular weight by Western-blot: 120 kDa

ELISA, IHC, IF, WB

Human; other species not tested.

Arc 1 antibody; Cadherin 1 antibody; CAM 120/80 antibody; CD324 antibody; CDH1 antibody; CDHE antibody; E cadherin antibody; ECAD antibody; E-cadherin antibody; Epithelial cadherin antibody; LCAM antibody; UVO antibody; Uvomorulin antibody

Mouse IgG2b

This antibody was obtained by immunization of E-cadherin recombinant protein (Accession Number: BC141838). Purification method: Protein A purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CDH1 (cadherin 1) or CAM 120/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. It has been regarded as a marker for spermatogonial stem cells in mice(PMID:23509752). E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, α-, β-, and γ-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity, and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness.