New Articles List

Does PBS buffer affect cell adhesion?

Cell adhesion is a pH-dependent phenomenon: the cells required Mg2+ or Ca2+ for attachment to substrates at pH higher than the isoelectric point of the proteins coating a plastic surface, but not at lower pH. With increasing pH from 3.4, cell adhesiv...

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Features of catalytic residues in enzyme active sites

Knowledge and improved understanding of the properties of enzyme active sites and their assorted catalytic mechanisms is vital for novel protein design and predicting protein function from structure. Crystallographic and NMR studies of enzymes have ...

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Commonly used protein pocket/cavity prediction tools

Tool Description Link CASTp Computed Atlas of Surface Topography of proteins (CASTp) provides pockets located on protein surfaces and voids buried in the interior of proteins. CASTp DEPTH Depth measures the closest distance of a residue/atom to bulk...

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How to Improve Peptide Stability?

Many of the "tricks" used by chemists to enhance activity and stability, by protecting peptides against both endo- and exo-peptidases, can also be found in active peptides of microbial or marine origin: D-amino acids or unusual amino acids instead o...

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Key molecule behind obesity to diabetes

On October 11th, the journal Cell Metabolism published a new article entitled "Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance", revealing a key enzyme, protein kinase. Metabolic details of ...

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