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# How to convert human dose to animal dose?

The common perception of scaling of dose based on the body weight (mg/kg) alone is not the right approach. This is primarily because the biochemical, functional systems in species vary which in turn alter pharmacokinetics. Therefore, extrapolation of dose from animals to humans needs consideration of body surface area, pharmacokinetics, and physiological time to increase clinical trial safety.

## Human equivalent dose calculation based on body surface area*

*:Data obtained from FDA draft guidelines; HED:human equivalent dose

 Species Reference body  weight(kg) Body surface area(m2) To convert dose in mg/kg  to dose in mg/m2, multiply by Km To convert animal dose in mg/kg to HED in mg/kg, either Divide animal dose by multiply animal dose by Human 60.00 1.620 37 - - Mouse 0.02 0.007 3 12.3 0.081 Hamster 0.08 0.016 5 7.4 0.135 Rat 0.15 0.025 6 6.2 0.162 Ferret 0.30 0.043 7 5.3 0.189 Guinea pig 0.40 0.050 8 4.6 0.216 Rabbit 1.80 0.150 12 3.1 0.324 Dog 10.00 0.500 20 1.8 0.541 Monkeys(rhesus) 3.00 0.250 12 3.1 0.324 Marmoset 0.35 0.060 6 6.2 0.162 Squirrel monkey 0.60 0.090 7 5.3 0.189 Baboon 12.00 0.600 20 1.8 0.541 Micro pig 20.00 0.740 27 1.4 0.73 Mini pig 40.00 1.140 35 1.1 0.946

Human dose (mg/kg) to mouse dose (mg/kg) - multiply by 12.3

Human dose (mg/kg) to rat dose (mg/kg) - multiply by 7.4

Human dose (mg/kg) to guinea pig dose (mg/kg) - multiply by 4.6

Human dose (mg/kg) to rabbit dose (mg/kg) - multiply by 3.1

Human dose (mg/kg) to dog dose (mg/kg) - multiply by 1.8

## References

Nair AB, Jacob S. A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm. 2016;7(2):27–31. doi:10.4103/0976-0105.177703

Souce: NovoPro    2019-05-31