| Tool | Description | Link |
|---|---|---|
| CASTp | Computed Atlas of Surface Topography of proteins (CASTp) provides pockets located on protein surfaces and voids buried in the interior of proteins. | CASTp |
| DEPTH | Depth measures the closest distance of a residue/atom to bulk solvent. | DEPTH |
| DogSiteScorer | An automated pocket detection and analysis tool based on support vector machine, which uses calculated size, shape and chemical features of automatically predicted. | DogSiteScorer |
| fpocket | A high performance protein pocket (cavity) detection algorithm based on Voronoi tessellation. | fpocket |
| GHECOM | A program for finding multi-scale pockets on protein surfaces using mathematical morphology. | GHECOM |
| LIGSITEcsc | An automatic detection of pockets on protein surface using the Connolly surface and the degree of conservation. | LIGSITEcsc |
| PDBinder | A bioinformatic tool for the prediction of small ligand binding sites, which compares a query protein against a library of binding and non-binding protein surface regions derivative from the PDB. | PDBinder |
| SiteHound | SiteHound finds protein regions that are probable to interact with ligands by computing interactions between a chemical probe and a protein structure. | SiteHound |
| CavityPlus | A web server for protein cavity detection with pharmacophore modelling, allosteric site identification and covalent ligand binding ability prediction | CavityPlus |
Souce: NovoPro 2019-05-10