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Product Name
Rat VEGF / VEGFA / VEGF165 recombinant protein
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Description
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis.
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Protein name
Vascular endothelial growth factor A
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Protein short names
VEGF; VPF; VEGF-A; MVCD1; MGC70609; RP1-261G23.1
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Uniprot ID
P16612
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Gene Name
Vegfa; Vegf
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat VEGF 164 isoform (AAA41211.1) (Met 1-Arg 190) was expressed.
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Protein Species
Rat
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Molecular weight
The secreted recombinant rat VEGF164 consists of 164 amino acids and has a predicted molecular mass of 19.2 kDa. The apparent molecular mass of the rat VEGF164 is approximately 25 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 86 % as determined by SDS-PAGE
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Activity
Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC).
The ED50 for this effect is typically 1-10 ng/ml. -
Validations
Rat VEGF164 / VEGFA Protein SDS-PAGE
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