Human VEGF / VEGFA / VEGF165 recombinant protein

Human VEGF / VEGFA / VEGF165 recombinant protein

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Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, inhibiting apoptosis and tumor growth. VEGF-A protein is also a vasodilator that increases microvascular permeability, thus it was originally referred to as vascular permeability factor.

Vascular endothelial growth factor A

RP1-261G23.1; VEGF; VPF; VEGF-A; MVCD1; MGC70609

P15692

VEGFA; VEGF

Baculovirus-Insect Cells

A DNA sequence encoding the human VEGF 121 isoform (P15692-9) (Met 1-Arg 147) was expressed.

Human

The recombinant human VEGF consists of 121 amino acids and has a predicted molecular mass of 14 kDa. The apparent molecular mass of the human VEGF 121 is approximately 17 and 19 kDa in SDS-PAGE under reducing conditions due to glycosylation.

(38.3+58.1) % as determined by SDS-PAGE

Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC).
The ED₅₀ for this effect is typically 0.5-2 ng/ml.