Human VEGFA recombinant protein (Native)

Human VEGFA recombinant protein (Native)

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Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, inhibiting apoptosis and tumor growth. VEGF-A protein is also a vasodilator that increases microvascular permeability, thus it was originally referred to as vascular permeability factor.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy

Vascular endothelial growth factor A

MVCD1,VEGF,VEGF165,VPF

P15692-3

Vascular endothelial growth factor A; VEGF-A; Vascular permeability factor; VPF

Baculovirus-Insect Cells

A DNA sequence encoding the human VEGF 183 isoform (P15692-3) (Met1-Arg209) was expressed.

Human

The recombinant human VEGF 183 isoform consists of 183 amino acids and has a predicted molecular mass of 21 kDa.

> 95 % as determined by SDS-PAGE.

Measured in a cell proliferation assay using human umbilical vein endothelial cells
(HUVEC) (Conn, G. et al. 1990, Proc. Natl. Acad. Sci. USA 87:1323.). The ED₅₀ for this effect is typically 10-50 ng/ml.