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Product Name
Rat Vegfa/Vegf recombinant protein
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Description
Vascular endothelial growth factor (VEGF/VEGF-A ) is originally known as vascular permeability factor (VPF). It belongs to the PDGF family with a cysteine-knot structure comprised of eight conserved cysteine residues, and reckoned as a potent mediator in the process of angiogenesis and vasculogenesis in either fetus or adult. VEGF is particularly expressed in supraoptic , paraventricular nuclei and the choroid plexus of the pituitary, and abundant in the corpus luteum of the ovary and in kidney glomeruli. The rat VEGF protein contains a putative 20 amino acids (aa) signal peptide, and alternative splicing of rat VEGF gene produces isoforms of 120, 144, 164 and 188 aa. Rat VEGF164 respectively displays 97% and 88% aa identity with that regions of mouse and human VEGF. VEGF can bind to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin, and play important roles in inducing endothelial cell proliferation, promoting cell migration, inhibiting apoptosis and inducing permeabilization of blood vessels.
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Protein name
vascular endothelial growth factor A(Vegfa)
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Protein short names
Vegf
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Uniprot ID
P16612-2
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Source/Expression Host
Yeast
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Expression Plasmid/cDNA
A DNA sequence encoding the Rat Vegfa/Vegf Ala27-Arg190 is expressed.
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Protein Species
Rat
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Purity
>95% as determined by SDS-PAGE.
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Validations
Rat Vegfa/Vegf recombinant protein
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