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  • Human FGFR3/CD333 (Fc Tag) recombinant protein

Human FGFR3/CD333 (Fc Tag) recombinant protein

Cat.#: 504277

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Product Information

  • Product Name
    Human FGFR3/CD333 (Fc Tag) recombinant protein
  • Documents
  • Description
    FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors.
  • Protein name
    Fibroblast growth factor receptor 3
  • Protein short names
    HSFGFR3EX; HBGFR; CEK2; CD333; FGFR-3; FR3; ACH; MFR3; JTK4; FLG-2; SAM3; FGFR3
  • Uniprot ID
    Q0IJ44
  • Gene Name
    FGFR3; JTK4
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human FGFR3 (NP_000133.1) (Met1-Gly375) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human FGFR3 consists 591 amino acids and predicts a molecular mass of 64.9 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Validations

    Human FGFR3 / CD333 Protein (Fc Tag)

    Human FGFR3 / CD333 Protein (Fc Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"