Human FGFR3/CD333 (IIIb) recombinant protein

Cat.#: 500406

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Product Information

  • Product Name
    Human FGFR3/CD333 (IIIb) recombinant protein
  • Documents
  • Description
    Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.
  • Protein name
    Fibroblast growth factor receptor 3
  • Protein short names
    MFR3; ACH; FR3; CEK2; HBGFR; CD333; FGFR-3; HSFGFR3EX; SAM3; FGFR3; FLG-2; JTK4
  • Uniprot ID
    Q0IJ44
  • Gene Name
    FGFR3; JTK4
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human FGFR3(alpha(IIIb)) (NP_001156685.1) (Met1-Gly377) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human FGFR3(alpha(IIIb)) consists 366 amino acids and predicts a molecular mass of 40 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Validations

    Human FGFR3 / CD333 Protein (alpha(IIIb), His Tag)

    Human FGFR3 / CD333 Protein (alpha(IIIb), His Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"