Anti-FGFR3 antibody

Anti-FGFR3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse Monoclonal to Human FGFR3

IHC-P

Human FGFR3/CD333

ACH antibody; CEK2 antibody; JTK4 antibody; CD333 antibody; HSFGFR3EX antibody; FR3 antibody; Mfr3 antibody; sam3 antibody; CD333 antibody; Flg-2 antibody; HBGFR antibody; Fgfr-3 antibody; ACH antibody; CD333 antibody; CEK2 antibody; FGFR3 antibody; Fgfr3 antibody; Fgfr-3 antibody; HBGFR antibody; HSFGFR3EX antibody; JTK4 antibody; CD333 antibody; FR3 antibody; Flg-2 antibody; Mfr3 antibody; sam3 antibody

Mouse IgG1

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the center region of the Human FGFR3/CD333. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy