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Product Name
Cynomolgus FGFR3/CD333 (Fc Tag) recombinant protein
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Description
FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors.
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Protein name
Fibroblast growth factor receptor
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Protein short names
FGFR-3; CD333; CEK2; HBGFR; HSFGFR3EX; ACH; MFR3; FR3; JTK4; FGFR3; SAM3; FLG-2
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Uniprot ID
F7FZR9
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Gene Name
FGFR3
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the cynomolgus FGFR3 (XP_001101108.1) (Met1-Gly375) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Cynomolgus
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Molecular weight
The recombinant cynomolgus FGFR3 is a disulfide-linked homodimer. The reduced monomer comprises 594 amino acids and has a calculated molecular mass of 65.1 KDa. The apparent molecular mass of the protein is approximately 99.9 KDa respectively in SDS-PAGE.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Cynomolgus FGFR3 Protein (Fc Tag) SDS-PAGE
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