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Product Name
Human EGFR/ERBB/ERBB1/HER1 (Fc tag) recombinant protein
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Description
EGFR is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling.
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Protein name
epidermal growth factor receptor(EGFR)
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Protein short names
ERBB; ERBB1; HER1
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Uniprot ID
P00533
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human EGFR/ERBB/ERBB1/HER1 Leu25-Ser645 is expressed with a Fc tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human EGFR/ERBB/ERBB1/HER1 (Fc tag) recombinant protein
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