-
Product Name
Human CASP3 Recombinant protein (His tag)
- Documents
-
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. {PubMed:21357690, PubMed:7596430}.
-
Protein name
Caspase-3
-
Protein short names
CPP32
-
Uniprot ID
P42574
-
Gene Name
CASP3; CPP32
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
29-175 aa encoded by XM_047416239 was inserted into PET30a vector
-
Protein Species
Human
-
Activity
Not tested.
-
Validations
Recombinant human CASP3 SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"