-
Product Name
Anti-Cleaved-Caspase-3 p17 Rabbit antibody
- Documents
-
Description
Cleaved-Caspase-3 p17 Rabbit polyclonal antibody
-
Tested applications
WB
-
Species reactivity
Mouse, Human
-
Isotype
Rabbit IgG
-
Preparation
Antigen: A synthetic peptide of mouse Caspase-3
-
Clonality
Polyclonal
-
Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
-
Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
-
Applications
WB: 1/1000
-
Validations
Western blot detection of Caspase-3 in C6,3T3,Hela cell lysates using Caspase-3 Rabbit pAb(1:1000 diluted).Predicted band size:32kDa.Observed band size:32/17kDa.
-
Background
Swiss-Prot Acc.P70677.Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage . Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"