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Cynomolgus TNFR2/CD120b/TNFRSF1B (Fc Tag) recombinant protein

Cat.#: 503164

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Product Information

  • Product Name
    Cynomolgus TNFR2/CD120b/TNFRSF1B (Fc Tag) recombinant protein
  • Documents
  • Description
    Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
  • Protein name
    Tumor necrosis factor receptor superfamily member 1B
  • Protein short names
    TNFRII; TNF-R-II; P75 TNF RECEPTOR; TNFR-1; TNFRSF1B; P75; TNFR2; TNFR-II; TBPII; TNF-R75; P75TNFR; TNFR80; TNF-RII; TNFBR; P75 TNFR; CD120B; TNF-R2; TNFR1B; TNF-ALPHAR2; RP23-157J11.1; TNFALPHA-R2
  • Uniprot ID
    F7EAE4
  • Gene Name
    TNFRSF1B
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the cynomolgus TNFRSF1B (F7EAE4) (Met1-Asp257) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Cynomolgus
  • Molecular weight
    The recombinant cynomolgus TNFRSF1B is a disulfide-linked homodimer. The reduced monomer comprises 476 amino acids and has a calculated molecular mass of 52.1 KDa.The apparent molecular mass of the protein is approximately 68 KDa respectively in SDS-PAGE.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to inhibit the TNFα mediated cytotoxicity in the L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D.
    The ED50 for this effect is typically 2-10 ng/mL in the presence of 1 ng/mL of cynoTNFα.
  • Validations

    Cynomolgus TNFR2 / CD120b / TNFRSF1B Protein (Fc Tag) SDS-PAGE

    Cynomolgus TNFR2 / CD120b / TNFRSF1B Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"