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Product Name
Human TNFRSF1B/TNFBR/TNFR2 (His tag) recombinant protein
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Description
Tumor necrosis factor receptor superfamily member 1B is a 461 amino acids protein that belongs to the TNFR (tumor necrosis factor receptor) superfamily characterized by cysteine-rich extracellular domains. It contains 4 TNFR-Cys repeats. TNFRII is expressed in fetal brain. TNFRII is strongly expressed at the cartilage-pannus junction, and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
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Protein name
TNF receptor superfamily member 1B(TNFRSF1B)
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Protein short names
TNFBR; TNFR2
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Uniprot ID
P20333
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human TNFRSF1B/TNFBR/TNFR2 Leu23-Asp257 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human TNFRSF1B/TNFBR/TNFR2 (His tag) recombinant protein
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