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Product Name
Mouse TNFR2/CD120b/TNFRSF1B (Fc Tag) recombinant protein
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Description
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity).
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Protein name
Tumor necrosis factor receptor superfamily member 1B
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Protein short names
TNF-R75; P75TNFR; TBPII; TNFR-II; TNFR2; P75; TNFR-1; TNFRSF1B; TNF-R-II; TNFRII; P75 TNF RECEPTOR; TNF-ALPHAR2; TNFR1B; TNFALPHA-R2; RP23-157J11.1; TNF-R2; CD120B; P75 TNFR; TNFBR; TNFR80; TNF-RII
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Uniprot ID
Q545P4
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Gene Name
Tnfrsf1b; Tnfr-2; Tnfr2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse TNFRSF1B (NP_035740.2) (Met 1-Gly 258) was fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse TNFRSF1B/Fc is a disulfide-linked homodimer. The reduced monomer consists of 477 amino acids and has a predicted molecular mass of 52.3 kDa. In SDS-PAGE under reducing conditions, rm TNFRSF1B/Fc monomer migrates as an approximately 65 kDa band due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D.
The ED50 for this effect is typically 4-16 ng/mL in the presence of 0.5 ng/mL of Recombinant Mouse TNFα. -
Validations
Mouse TNFR2 / CD120b / TNFRSF1B Protein (Fc Tag) SDS-PAGE
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