Rhesus DDR2/CD167b (Fc Tag) recombinant protein

Rhesus DDR2/CD167b (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.

Uncharacterized protein

TKT; DDR2; MIG20A; CD167B; RP11-572K18.1; TYRO10; NTRKR3; AW495251

F7HJQ2

DDR2; EGK_01556

Human Cells

A DNA sequence encoding the rhesus DDR2 (XP_001118219.1) (Met1-Arg399) was expressed with the Fc region of human IgG1 at the C-terminus.

Rhesus

The recombinant rhesus DDR2 comprises 619 amino acids and has a calculated molecular mass of 69.7 KDa.

> 95 % as determined by SDS-PAGE

1. Measured by its binding ability in a functional ELISA.
2. Immobilized Rat tail Collagen I at 10 μg/mL (100 μL/well) can bind Rhesus DDR2-Fc (Cat:501038).
The EC₅₀ of Rhesus DDR2-Fc (Cat:501038) is 0.23-0.55μg/mL.