Mouse DDR2/CD167b (His Tag) recombinant protein

Mouse DDR2/CD167b (His Tag) recombinant protein

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Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

Discoidin domain-containing receptor 2

CD167B; DDR2; MIG20A; TKT; AW495251; RP11-572K18.1; NTRKR3; TYRO10

Q62371

Ddr2; Ntrkr3; Tkt; Tyro10

Human Cells

A DNA sequence encoding the extracellular domain of mouse DDR2 (NP_072075.2) (Met 1-Arg 399) was expressed, with a polyhistidine tag at the C-terminus.

Mouse

The recombinant mouse DDR2 consists of 389 amino acids and has a predicted molecular mass of 44 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm DDR2 is approximately 80-90 kDa due to glycosylation.

> 95 % as determined by SDS-PAGE

Measured by its ability to bind rat tail Collagen I in a functional ELISA.