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  • Mouse TGFBR3 / Betaglycan (His Tag) recombinant protein

Mouse TGFBR3 / Betaglycan (His Tag) recombinant protein

Cat.#: 504260

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Product Information

  • Product Name
    Mouse TGFBR3 / Betaglycan (His Tag) recombinant protein
  • Documents
  • Description
    Betaglycan also known as transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan. TGFBR3 is a transforming growth factor (TGF)-beta type III receptor. This receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. TGFBR3 is the TGF-β component most commonly downregulated among localized human prostate cancer studies. TGFBR3 knockdown led to focus formation and enhanced expression of CD133, a marker found on prostate cancer stem cells. TGFBR3 is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFβ) and inhibin, two members of the TGFβ superfamily of growth factors that regulate many aspects of reproductive biology. TGFBR3 is known to be expressed in adult testis and ovary, but little is known about this receptor during gonadogenesis.
  • Protein name
    Discoidin domain-containing receptor 2
  • Protein short names
    BGCAN; 1110036H20RIK; BETAGLYCAN; TBRIII; AW215636; AU015626; TGFBR3
  • Uniprot ID
    Q62371
  • Gene Name
    Ddr2; Ntrkr3; Tkt; Tyro10
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of mouse TGFBR3 (NP_072075.2) (Met 1-Arg 399) was expressed, with a polyhistidine tag at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse TGFBR3 consists of 774 amino acids and has a predicted molecular mass of 86.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmTGFBR3 is approximately 80-90 kDa due to glycosylation.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Mouse TGFBR3 / Betaglycan Protein (His Tag) SDS-PAGE

    Mouse TGFBR3 / Betaglycan Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"