Rat DDR2/CD167b (His Tag) recombinant protein

Cat.#: 501961

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Product Information

  • Product Name
    Rat DDR2/CD167b (His Tag) recombinant protein
  • Documents
  • Description
    Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.
  • Protein name
    Discoidin domain receptor tyrosine kinase 2
  • Protein short names
    TKT; MIG20A; DDR2; CD167B; NTRKR3; TYRO10; RP11-572K18.1; AW495251
  • Uniprot ID
    B1WC09
  • Gene Name
    Ddr2; rCG_46328
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rat DDR2 (B1WC09) (Met1-Arg399) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Rat
  • Molecular weight
    The recombinant rat DDR2 comprises 387 amino acids and predicts a molecular mass of 43.9 kDa. The apparent molecular mass of the recombinant protein is approximately 58 kDa in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Validations

    Rat DDR2 Kinase / CD167b Protein (His Tag) SDS-PAGE

    Rat DDR2 Kinase / CD167b Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"