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Product Name
Mouse HER2/ErbB2 (Fc Tag) recombinant protein
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Description
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
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Protein name
Receptor tyrosine-protein kinase erbB-2
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Protein short names
C-ERBB-2; NEU; RP23-355L10.8; C-NEU; HER-2; ERBB2; TKR1; C-ERBB2; HER-2/NEU; ERBB-2; NGL; HER2; CD340; MKIAA3023; MLN19
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Uniprot ID
P70424
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Gene Name
Erbb2; Kiaa3023; Neu
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse ERBB2 (P70424) extracellular domain (Met 1-Thr 653) was fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse ERBB2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 872 amino acids and has a calculated molecular mass of 96.7 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 120-130 kDa in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Mouse HER2 / ErbB2 Protein (Fc Tag) SDS-PAGE
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