Human HER2/ErbB2 (His & GST Tag) recombinant protein

Cat.#: 503179

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Product Information

  • Product Name
    Human HER2/ErbB2 (His & GST Tag) recombinant protein
  • Documents
  • Description
    Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
  • Protein name
    Receptor tyrosine-protein kinase erbB-2
  • Protein short names
    C-ERBB-2; ERBB2; C-NEU; HER-2; RP23-355L10.8; NEU; MKIAA3023; CD340; NGL; HER2; HER-2/NEU; ERBB-2; TKR1; C-ERBB2; MLN19
  • Uniprot ID
    X5DNK3
  • Gene Name
    ERBB2; HER2; MLN19; NEU; NGL
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the cytoplasmic domain (Lys 676-Val 1255) of human ErbB2 (NP_004439.2) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human ErbB2 (676-1255)/GST chimera consists of 817 amino acids and predictes a molecular mass of 92 kDa. It migrates as an approximately 100 KDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 75 % as determined by SDS-PAGE
  • Activity
    No Kinase Activity
  • Validations

    Human HER2 / ErbB2 / CD340 (676-1255) Protein (His & GST Tag) SDS-PAGE

    Human HER2 / ErbB2 / CD340 (676-1255) Protein (His & GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"