Mouse HER2/ErbB2 (His Tag) recombinant protein

Mouse HER2/ErbB2 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

Receptor tyrosine-protein kinase erbB-2

C-ERBB-2; ERBB2; RP23-355L10.8; C-NEU; HER-2; NEU; CD340; MKIAA3023; HER2; NGL; TKR1; C-ERBB2; HER-2/NEU; ERBB-2; MLN19

P70424

Erbb2; Kiaa3023; Neu

Human Cells

A DNA sequence encoding the mouse ERBB2 (P70424) extracellular domain (Met 1-Thr 653) was expressed, with a C-terminal polyhistidine tag.

Mouse

The secreted recombinant mouse ERBB2 comprises 642 amino acids and has a calculated molecular mass of 71.1 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 100-110 kDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE