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Product Name
Human HER2/ErbB2 recombinant protein
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Description
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
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Protein name
Receptor tyrosine-protein kinase erbB-2
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Protein short names
ERBB-2; C-ERBB-2; HER-2/NEU; C-ERBB2; TKR1; NGL; HER2; MKIAA3023; CD340; NEU; HER-2; C-NEU; RP23-355L10.8; ERBB2; MLN19
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Uniprot ID
X5DNK3
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Gene Name
ERBB2; HER2; MLN19; NEU; NGL
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human ERBB2 (NP_004439.2) (Met1-Thr652) was expressed with five amino acids (DDDDK) at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human ERBB2 consists 636 amino acids and predicts a molecular mass of 70 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Human HER2 / ErbB2 Protein
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