-
Product Name
Anti-HER2/ErbB2 antibody
- Documents
-
Description
Rabbit polyclonal to HER2/ErbB2
-
Tested applications
ELISA, WB
-
Species reactivity
Mouse HER2 / ErbB2
-
Alternative names
NEU antibody; NGL antibody; HER2 antibody; TKR1 antibody; CD340 antibody; HER-2 antibody; MLN19 antibody; HER-2/neu antibody; Neu antibody; HER2 antibody; HER-2 antibody; c-neu antibody; Erbb-2 antibody; c-erbB2 antibody; mKIAA3023 antibody; CD340 antibody; c-erbB2 antibody; c-erbB-2 antibody; c-neu antibody; Erbb2 antibody; ERBB2 antibody; Erbb-2 antibody; HER2 antibody; HER2 antibody; HER-2 antibody; HER-2 antibody; HER-2/neu antibody; mKIAA3023 antibody; Neu antibody; NEU antibody; NGL antibody; RP23-355L10.8 antibody; TKR1 antibody
- Immunogen
-
Isotype
Rabbit IgG
-
Preparation
Produced in rabbits immunized with purified, recombinant Mouse HER2 / ErbB2 (rh HER2 / ErbB2; P70424; Met1-Thr653). HER2 / ErbB2 specific IgG was purified by Mouse HER2 / ErbB2 affinity chromatography.
-
Clonality
Polyclonal
-
Formulation
0.2 μm filtered solution in PBS
-
Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-20 μg/ml
ELISA:0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse HER2 / ErbB2. The detection limit for Mouse HER2 / ErbB2 is 0.00245 ng/well.
-
Validations
HER2 / ErbB2 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
-
Background
Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
-
References
- Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"