Human HER2/ErbB2 (His Tag) recombinant protein

Cat.#: 503895

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Product Information

  • Product Name
    Human HER2/ErbB2 (His Tag) recombinant protein
  • Documents
  • Description
    Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
  • Protein name
    Receptor tyrosine-protein kinase erbB-2
  • Protein short names
    TKR1; C-ERBB2; HER-2/NEU; ERBB-2; C-ERBB-2; CD340; MKIAA3023; HER2; NGL; NEU; MLN19; ERBB2; RP23-355L10.8; C-NEU; HER-2
  • Uniprot ID
    P04626
  • Gene Name
    ERBB2; HER2; MLN19; NEU; NGL
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human ERBB2 (AAA75493.1) (Pro489-Cys630) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human ERBB2 consists of 153 amino acids and predicts a molecular mass of 17.1 kDa.
  • Purity
    > (48.9+40.2) % as determined by SDS-PAGE.
  • Validations

    Human HER2 / ErbB2 Protein (domain IV) (His Tag)

    Human HER2 / ErbB2 Protein (domain IV) (His Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"