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Product Name
Human HER2/ErbB2 (His Tag) recombinant protein
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Description
Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
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Protein name
Receptor tyrosine-protein kinase erbB-2
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Protein short names
TKR1; C-ERBB2; HER-2/NEU; ERBB-2; C-ERBB-2; CD340; MKIAA3023; HER2; NGL; NEU; MLN19; ERBB2; RP23-355L10.8; C-NEU; HER-2
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Uniprot ID
P04626
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Gene Name
ERBB2; HER2; MLN19; NEU; NGL
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human ERBB2 (AAA75493.1) (Pro489-Cys630) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human ERBB2 consists of 153 amino acids and predicts a molecular mass of 17.1 kDa.
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Purity
> (48.9+40.2) % as determined by SDS-PAGE.
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Validations
Human HER2 / ErbB2 Protein (domain IV) (His Tag)
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