Rat ICAM-1/CD54 (Fc Tag) recombinant protein

Rat ICAM-1/CD54 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.

Intercellular adhesion molecule 1

MALA-2; MYD10; LY-47; P3.58; MGC6195; ICAM1; ICAM-1; CD54; BB2

Q00238

Icam1; Icam-1

Human Cells

A DNA sequence encoding the rat Icam1 (NP_037099.1) (Met1-Thr493) was expressed with the Fc region of human IgG1 at the C-terminus.

Rat

The recombinant rat Icam1 consists 699 amino acids and predicts a molecular mass of 77.6 kDa.

> 95 % as determined by SDS-PAGE.