Human ICAM1 (His tag) recombinant protein

Human ICAM1 (His tag) recombinant protein

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Inter-Cellular Adhesion Molecule 1 (ICAM1) is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. As an endothelial and leukocyte-associated transmembrane protein, ICAM1 is well known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration. The presence of heavy glycosylation and other structural characteristics lend ICAM1 binding sites for a number of immune-associated ligands. Notably, ICAM-1 binds to macrophage adhesion ligand-1 (Mac-1; ITGB2 / ITGAM), leukocyte function associated antigen-1 (LFA-1/integrin), and fibrinogen.ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds.

intercellular adhesion molecule 1(ICAM1)

P05362

Human Cells

A DNA sequence encoding the Human ICAM1 Gln28-Glu480 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.