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Product Name
Rabbit IL-1 beta recombinant protein
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Description
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
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Protein name
Interleukin-1 beta
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Protein short names
IL-1B; IL-1 BETA; IL-1; IL1F2; IL-1BETA; IL1B; IL1-BETA
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Uniprot ID
P14628
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Gene Name
IL1B
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the rabbit IL1B (NP_001075670.1) (Ala117-Ser268) was expressed with with an initial Met at the N-terminus.
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Protein Species
Rabbit
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Molecular weight
The recombinant rabbit IL1B consists of 153 amino acids and predicts a molecular mass of 17.5 KDa. It migrates as an approximately 19 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons,J.A. et al. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens,M.J. et al. (eds): IRL Press. 272.
The ED50 for this effect is typically 1-5 pg/mL. -
Validations
Rabbit IL-1 beta / IL1B Protein SDS-PAGE
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