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Product Name
Rat IL-1 beta (pro form, His Tag) recombinant protein
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Description
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).
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Protein name
Interleukin-1 beta
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Protein short names
IL-1B; IL1F2; IL-1; IL-1 BETA; IL1B; IL1-BETA; IL-1BETA
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Uniprot ID
Q63264
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Gene Name
Il1b
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the pro form of rat IL1B (Q63264-1) (Met 1-Ser 268) was fused with a polyhistidine tag at the N-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat IL1B comprises 279 amino acids and predicts a molecular mass of 32.1 kDa. The apparent molecular mass of the rat IL1B is approximately 35 kDa in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Rat IL-1 beta / IL1B Protein (pro form, His Tag) SDS-PAGE
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