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Mouse IL-1 beta recombinant protein

Cat.#: 502137

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Product Information

  • Product Name
    Mouse IL-1 beta recombinant protein
  • Documents
  • Description
    Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
  • Protein name
    Interleukin-1 beta
  • Protein short names
    IL-1B; IL-1 BETA; IL-1; IL1F2; IL-1BETA; IL1-BETA; IL1B
  • Uniprot ID
    P10749
  • Gene Name
    Il1b
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mature form of mouse IL1? (P10749) (Val 118-Ser 269) was expressed, with an initial Met at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse IL1? consists of 153 amino acids and has a predicted molecular mass of 17.5 kDa. It migrates as an approximately 19 kDa band in SDS-PAGE under reducing conditions as predicted.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    1. Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is typically 2-10 pg/mL.
    2. Measured by its ability to bind human IL1R1 in a functional ELISA.
    3. Measured by its ability to bind mouse IL1R1 in a functional ELISA.
  • Validations

    Mouse IL-1 beta / IL1B Protein SDS-PAGE

    Mouse IL-1 beta / IL1B Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"