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Canine IL-1 beta recombinant protein

Cat.#: 502015

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Special Price 244.8 USD

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Product Information

  • Product Name
    Canine IL-1 beta recombinant protein
  • Documents
  • Description
    Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).
  • Protein name
    Interleukin-1 beta
  • Protein short names
    IL1-BETA; IL1B; IL-1BETA; IL1F2; IL-1; IL-1 BETA; IL-1B
  • Uniprot ID
    Q28292
  • Gene Name
    IL1B
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mature form of canine IL1B (Q28292) (Ala 115-Ser 266) was expressed, with an initial Met at the N-terminus.
  • Protein Species
    Canine
  • Molecular weight
    The recombinant canine IL1B consists of 153 amino acids and has a calculated molecular mass of 17.6 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 17 kDa band.
  • Purity
    > 96 % as determined by SDS-PAGE
  • Activity
    1. Measured by its ability to bind human IL1R1 in a functional ELISA.
    2. Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is typically 2-12 pg/mL.
  • Validations

    Canine IL-1 beta / IL1B Protein SDS-PAGE

    Canine IL-1 beta / IL1B Protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"