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  • Human IL12B/IL-12B (His Tag) recombinant protein

Human IL12B/IL-12B (His Tag) recombinant protein

Cat.#: 503329

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Product Information

  • Product Name
    Human IL12B/IL-12B (His Tag) recombinant protein
  • Documents
  • Description
    Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity.
  • Protein name
    Interleukin-12 subunit beta
  • Protein short names
    P40; CLMF2; CLMF; NKSF; IL12B; IMD28; IL-12P40; NKSF2; IL-12B; IMD29; RP23-388G23.1; IL12P40
  • Uniprot ID
    P29460
  • Gene Name
    IL12B; NKSF2
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the p40 subunit of human IL12, termed as IL12B (NP_002178.2) (Met 1-Ser 328) was fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human IL12B consists of 317 amino acids and has a predicted molecular mass of 36.2 kDa. As a result of glycosylation, the apparent molecular mass of rhIL12B is approximately 40-50 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    1. Measured by its ability to bind biotinylated recombinant human IL12RB1 in a functional ELISA.
    2. Measured by its ability to bind biotinylated Human IL12A-his in functional ELISA.
  • Validations

    Human IL12B / P40 Protein (His Tag) SDS-PAGE

    Human IL12B / P40 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"