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Product Name
Anti-Semaphorin 4D/SEMA4D/CD100 antibody
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Description
Rabbit polyclonal to Semaphorin 4D/SEMA4D/CD100
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Tested applications
ELISA, WB
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Species reactivity
Human SEMA4D / CD100
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Alternative names
C9orf164 antibody; CD100 antibody; CD100 antibody; coll-4 antibody; coll-4 antibody; FLJ33485 antibody; FLJ34282 antibody; FLJ39737 antibody; M-sema-G antibody; SEMA4D antibody; Semacl2 antibody; SEMAJ antibody; Semaphorin 4D antibody; FLJ46484 antibody; MGC169138 antibody; MGC169141 antibody; CD100 antibody; SEMAJ antibody; coll-4 antibody; C9orf164 antibody; M-sema-G antibody; CD100 antibody; Semaj antibody; Semcl2 antibody; coll-4 antibody; Semacl2 antibody; Sema4d antibody; Semaj antibody; Semaphorin 4D antibody; Semcl2 antibody; XXyac-YM68G7.1 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human SEMA4D / CD100 (rh SEMA4D / CD100; Q92854-1; Met 1-Arg 734). SEMA4D / CD100 specific IgG was purified by Human SEMA4D / CD100 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS with 5% trehalose
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 5-20 μg/mL
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human SEMA4D. The detection limit for Human SEMA4D is approximately 0.00245 ng/well.
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Validations
Semaphorin 4D / SEMA4D / CD100 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Background
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"