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Product Name
Mouse Semaphorin 4D/SEMA4D/CD100 (His Tag) recombinant protein
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Description
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA (By similarity).
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Protein name
Semaphorin-4D
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Protein short names
FLJ33485; FLJ46484; XXYAC-YM68G7.1; MGC169141; C9ORF164; M-SEMA-G; SEMAPHORIN 4D; COLL-4; SEMACL2; SEMA4D; FLJ34282; MGC169138; CD100; FLJ39737; SEMCL2; SEMAJ
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Uniprot ID
O09126
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Gene Name
Sema4d; Semacl2; Semaj
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse SEMA4D (NP_038688.2) extracellular domain (Met 1-Arg 733) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse SEMA4D comprises 721 amino acids and has a calculated molecular mass of 80.2 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 100-110 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 96 % as determined by SDS-PAGE
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Activity
Measured by its ability to bind human SEMA4A in a functional ELISA.
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Validations
Mouse Semaphorin 4D / SEMA4D / CD100 Protein (His Tag) SDS-PAGE
Related Products / Services
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