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  • Mouse UCHL3 (His Tag) recombinant protein

Mouse UCHL3 (His Tag) recombinant protein

Cat.#: 500004

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Product Information

  • Product Name
    Mouse UCHL3 (His Tag) recombinant protein
  • Documents
  • Description
    Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome.
  • Protein name
    Ubiquitin carboxyl-terminal hydrolase isozyme L3
  • Protein short names
    UCHL3; UCH-L3; RP11-173B14.3
  • Uniprot ID
    Q9JKB1
  • Gene Name
    Uchl3
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse UCHL3 (Q9JKB1) (Glu 2-Ala 230) was expressed, with a polyhistide tag at the N-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse UCHL3 consisting of 240 amino acids and has a calculated molecular mass of 27.5 kDa. rm UCHL1 migrates as an approximately 30 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    Measured by the hydrolysis of UbiquitinAMC. The specific activity is >14000 pmoles/min/μg.
  • Validations

    Mouse UCHL3 / UCH-L3 Protein (His Tag) SDS-PAGE

    Mouse UCHL3 / UCH-L3 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"