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Product Name
Rabbit Coagulation Factor III / Tissue Factor / CD142 (His Tag) recombinant protein
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Description
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Tissue factor is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. Tissue factor is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes. Coagulation Factor III is a transmembrane glycoprotein that localizes the coagulation serine protease factor VII/VIIa (FVII/VIIa) to the cell surface. The primary function of TF is to activate the clotting cascade. The TF:FVIIa complex also activates cells by cleavage of a G-protein coupled receptor called protease-activated receptor 2 (PAR2). TF is expressed by tumor cells and contributes to a variety of pathologic processes, such as thrombosis, metastasis, tumor growth, and tumor angiogenesis. As a key regulator of haemostasis and angiogenesis, it is also involved in the pathology of several diseases, including cardiovascular, inflammatory and neoplastic conditions.
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Protein name
Tissue factor
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Protein short names
CD142; CF3; F3; AA409063; TISSUE FACTOR; CF-3; TF; COAGULATION FACTOR III; THROMBOPLASTIN; TFA
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Uniprot ID
P24055
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Gene Name
F3
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rabbit F3 (NP_001075760.1) (Met1-Met250) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Rabbit
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Molecular weight
The recombinant rabbit F3 consists 229 amino acids and predicts a molecular mass of 26.4 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
F3 protein SDS-PAGE
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