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Product Name
Anti-CD36/SCARB3 antibody
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Description
Rabbit polyclonal to CD36/SCARB3
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Tested applications
ELISA, WB
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Species reactivity
Rat CD36 / SCARB3
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Alternative names
fat antibody; CD36 antibody; FAT antibody; GP4 antibody; GP3B antibody; GPIV antibody; CHDS7 antibody; PASIV antibody; SCARB3 antibody; BDPLT10 antibody; FAT antibody; GPIV antibody; Scarb3 antibody; CD36 antibody; CHDS7 antibody; FAT antibody; GP3B antibody; GP4 antibody; GPIIIB antibody; GPIV antibody; GPIV antibody; PAS IV antibody; PAS-4 antibody; PASIV antibody; SCARB3 antibody; Scarb3 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Rat CD36 / SCARB3 (rh CD36 / SCARB3; Q66HI4; Gly30-Lys439). CD36 / SCARB3 specific IgG was purified by Rat CD36 / SCARB3 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 5-10 μg/ml
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Rat CD36 / SCARB3. The detection limit for Rat CD36 / SCARB3 is < 0.039 ng/well.
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Validations
CD36 / SCARB3 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Background
The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 36 (CD36), also known as FAT, SCARB3, GP88, glycoprotein IV (gpIV) and glycoprotein IIIb (gpIIIb), is a member of the CD system as well as the class B scavenger receptor family of cell surface proteins. CD36 can be found on the surface of many cell types in vertebrate animals and it consists of 472 amino acids and is extensively glycosylated. It is an integral membrane protein primarily serving as receptors for thrombospondin and collagen and by the erythrocytes infected with the human malaria parasite. The role of CD36 as a cell surface receptor has been extended to that of a signal transduction molecule.
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References
- Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
- Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
- Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
- Greenwalt RH, et al. (1992) Membrane glycoprotein in CD36: a review of its roles in adherence, signal transduction, and transfusion medicine. The journal of the American society of hematology. 80 (5): 1105-15.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"