Anti-Coagulation Factor III / Tissue Factor / CD142 antibody

Anti-Coagulation Factor III / Tissue Factor / CD142 antibody

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• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to Coagulation Factor III / Tissue Factor / CD142

FCM

Mouse Coagulation Factor III / Tissue Factor / CD142

TF antibody; TFA antibody; CD142 antibody; TF antibody; Cf3 antibody; Cf-3 antibody; CD142 antibody; AA409063 antibody; AA409063 antibody; Cf-3 antibody; Tissue Factor antibody; CD142 antibody; CD142 antibody; Cf3 antibody; Coagulation Factor III antibody; Coagulation Factor III antibody; F3 antibody; TF antibody; TF antibody; TFA antibody; thromboplastin antibody; F3 antibody; Tissue Factor antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Coagulation Factor III / Tissue Factor / CD142 (rM Coagulation Factor III / Tissue Factor / CD142; NP_034301.3; Met1-Glu251).

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Tissue factor is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. Tissue factor is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes. Coagulation Factor III is a transmembrane glycoprotein that localizes the coagulation serine protease factor VII/VIIa (FVII/VIIa) to the cell surface. The primary function of TF is to activate the clotting cascade. The TF:FVIIa complex also activates cells by cleavage of a G-protein coupled receptor called protease-activated receptor 2 (PAR2). TF is expressed by tumor cells and contributes to a variety of pathologic processes, such as thrombosis, metastasis, tumor growth, and tumor angiogenesis. As a key regulator of haemostasis and angiogenesis, it is also involved in the pathology of several diseases, including cardiovascular, inflammatory and neoplastic conditions.

• Morrissey JH. (2004) Tissue factor: a key molecule in hemostatic and nonhemostatic systems. Int J Hematol. 79(2): 103-8.
• Milsom C, et al. (2008) Tissue factor and cancer. Pathophysiol Haemost Thromb. 36(3-4): 160-76.
• Kasthuri RS, et al. (2009) Role of tissue factor in cancer. J Clin Oncol. 27(29): 4834-8.