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Product Name
Rabbit CD80 (His tag) recombinant protein
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Description
Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.
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Protein name
CD80 molecule(CD80)
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Uniprot ID
P42070
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Rabbit CD80 Gly33-Gln241 is expressed with a 6His tag at the C-terminus.
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Protein Species
Rabbit
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Purity
>95% as determined by SDS-PAGE.
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Validations
Rabbit CD80 (His tag) recombinant protein
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