Mouse CD80/B7-1 (His Tag) recombinant protein

Cat.#: 503774

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Product Information

  • Product Name
    Mouse CD80/B7-1 (His Tag) recombinant protein
  • Documents
  • Description
    The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
  • Protein name
    T-lymphocyte activation antigen CD80
  • Protein short names
    LY53; MIC17; LY-53; CD28L; CD80; BB1; B7; B7-1; LAB7; B7.1; CD28LG; TSA1; B71; CD28LG1
  • Uniprot ID
    Q00609
  • Gene Name
    Cd80; B7
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse CD80 (Q00609-1) extracellular domain (Met 1-Lys 245) was expressed, with a polyhistidine tag at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse CD80 consists of 219 amino acids and has a predicted molecular mass of 25.1 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm CD80 is approximately 48-50 kDa due to glycosylation.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to bind recombinant mouse CD28 in a functional ELISA.
  • Validations

    Mouse CD80 / B7-1 / CD28LG Protein (His Tag) SDS-PAGE

    Mouse CD80 / B7-1 / CD28LG Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"