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Product Name
Rat CD80/B7-1 (Fc Tag) recombinant protein
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Description
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
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Protein name
B7-1
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Protein short names
B7; LY53; LY-53; MIC17; B7.1; CD80; CD28L; B7-1; LAB7; BB1; B71; TSA1; CD28LG1; CD28LG
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Uniprot ID
Q62680
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Gene Name
Cd80; B7-1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat Cd80 (AAB60503.1) (Met1-Gln248) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat Cd80 consists 451 amino acids and predicts a molecular mass of 51 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Rat CD80 / B7-1 Protein (Fc Tag)
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"