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Product Name
Cynomolgus CD80/EGK_11324 (His tag) recombinant protein
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Description
Cynomolgus Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.CD80 plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
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Protein name
CD80 molecule(CD80)
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Protein short names
EGK_11324
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Uniprot ID
G7MKE2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Cynomolgus CD80/EGK_11324 Val35-Asn242 is expressed with a 6His tag at the C-terminus.
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Protein Species
Cynomolgus
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Purity
>95% as determined by SDS-PAGE.
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Validations
Cynomolgus CD80/EGK_11324 (His tag) recombinant protein
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