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  • Mouse ACE2 / Angiotensin-Converting Enzyme 2 (His & Fc Tag) recombinant protein

Mouse ACE2 / Angiotensin-Converting Enzyme 2 (His & Fc Tag) recombinant protein

Cat.#: 503854

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Product Information

  • Product Name
    Mouse ACE2 / Angiotensin-Converting Enzyme 2 (His & Fc Tag) recombinant protein
  • Documents
  • Description
    Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. ACE2 also has an important role in blood pressure control. This enzyme, an homolog of ACE, hydrolyzes angiotensin (Ang) I to produce Ang-(1-9), which is subsequently converted into Ang-(1-7) by a neutral endopeptidase and ACE. ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II. Thus, the major biologically active product of ACE2 is Ang-(1-7), which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. In the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis.
  • Protein name
    Angiotensin-converting enzyme 2
  • Protein short names
    2010305L05RIK; RP23-330O24.1; DKFZP434A014; ACE2; ACEH
  • Uniprot ID
    Q8R0I0
  • Gene Name
    Ace2
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse ACE2 isoform 1 (Q8R0I0-1) extracellular domain (Met 1-Thr 740) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The secreted recombinant mouse ACE2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 971 amino acids and has a predicted molecular mass of 112 kDa. As a result of glycosylation, it migrates as an approximately 130 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Mouse ACE2 / Angiotensin-Converting Enzyme 2 Protein (His & Fc Tag) SDS-PAGE

    Mouse ACE2 / Angiotensin-Converting Enzyme 2 Protein (His & Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"